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butabarbital will decrease the extent or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.diazepam will enhance the amount or result of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. If coadministration of lonafarnib (a delicate CYP3A subst